If you have some information of this trials or for another I have pleasure to include in this site (send e-mail to [email protected] )
1) Research phase I clinical trial of full-length dystrophin plasmid DNA in Duchenne/Becker muscular dystrophies - from Institute de Myologie and Transgene (France):
The most recent information obtained by our friend from Norway, Berit Sofie:
e-mail from Serge Braun, PharmD, PhD - Vice-President Research Transgene S.A.:
Serge Braun
2) Phase I clinical trial to evaluate in humans the efficacy of mioblast therapy for Duchenne Muscular Dystrophy - Dr. Jacques P. Tremblay, Canada
http://www.newswire.ca/releases/October2002/16/c1427.html
The most recent information obtained by our friend Uli Gehrt from Germany:
Dear Mr Gehrt, thank you for your
interest in my research work. We have started a Phase I clinical trial!
Myoblasts will be transplanted in only 1 cm cube of the Tibialis muscle. A
muscle biopsy will be made 1 month later to assess the presence of dystrophin
positive fibers. We will have the results of 10 patients. I hope by the end of
2003.
Have a Merry Christmas!
Jacques P. Tremblay
3) Albuterol in DMD - UCLA, USA
The most recent information obtained by our friend Berit Sofie from Norway:
We have completed a pilot study and
found that when the children were on long acting albuterol pills they exhibited
an average of an 8% increase in strength compared to a slight loss in strength
while on the placebo pills. We are now performing a larger scale study with 25
children and some slight changes in the protocol to further study this treatment.
The youngest child in our study so far was 5 years old.
Sincerely
Eileen Fowler, PhD, PT
4) An open-label pilot study of Oxatomide in steroid-naive Duchenne muscular dystrophy
5) An open-label pilot study of Coenzyme Q10 in steroid-treated Duchenne muscular dystrophy
7) Study of Albuterol and Oxandrolone in Patients With Facioscapulohumeral Dystrophy (FSHD)
8) Study of Inherited Neurological Disorders
9) Phase I Clinical Trial Utilizing Gene Therapy for Limb Girdle Muscular Dystrophy: a, b, g, or d-Sarcoglycan Sarcoglycan Gene Delivered with Intramuscular Instillations of Adeno-Associated Vectors NEW
Principal investigator - Dr. Jerry
Mendell
Ohio State University
Columbus, Ohio
USA
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10757357&dopt=Abstract
10) Registry of Arrhythmias in Myotonic Muscular Dystrophy (MMD). A Long Term Study To Evaluate Heart Rhythm Disturbance in Subjects With MMD NEW
http://www.centerwatch.com/patient/studies/stu41452.html
11) Prednisone and Cyclosporin A in Duchenne Muscular Dystrophy - Clinical trial in Germany