2006 Top Ten: Advances in Pharmacological Approach in DMD

1) PTC THERAPEUTICS ANNOUNCES ENCOURAGING PRELIMINARY PHASE 2 RESULTS OF PTC124 IN DUCHENNE MUSCULAR DYSTROPHY - USA

2)  Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy - Italy

3) Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors (Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy) - Italy

 4) Drug may help treat muscular dystrophy (Angiotensin II Type 1 Receptor Blockade Improves TGFb-induced Failure of Muscle Regeneration in the mdx Mouse Model of Duchenne Muscular Dystrophy) - USA

 5) Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNFalpha function with Etanercept in mdx mice - Australia

 6) Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice - Australia

 7) Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue - Australia

 8) Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice - Italy

 9) First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant - Italy

 10) Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice - Australia

 

Researchs with Supplements

 Persistent and improved functional gain in mdx dystrophic mice after treatment with L-arginine and deflazacort - Canada

 Curcumin Attenuates Dystrophic Pathology in mdx Mice through Inhibiting NF-κB Activation- unpublished - China

 Green tea extract and its major polyphenol (–)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy - Switzerland



 

Researchs with Steroids

 Weekly oral prednisolone improves survival and strength in male mdx mice - USA

Long-term benefits of deflazacort treatment for boys with Duchenne muscular dystrophy in their second decade - Canada

 

 

 

 

Research in Cardiac dysfunction

Left Ventricular Function and Response to Enalapril in Patients With Duchenne Muscular Dystrophy During the Second Decade of Life - USA

Beta-blocker therapy for cardiac dysfunction in patients with muscular dystrophy - Japan

Long-term administration of pirfenidone improves cardiac function in mdx mice - Australia